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Cambridge
Major Laboratories Inc - The Company
Cambridge Major Laboratories, Inc. is a service-based chemistry
outsourcing partner to the world's leading pharmaceutical and
biotechnology companies, producing pharmaceutical intermediates,
API's (preclinical to post-NDA), and other fine organic chemicals.
Specializing in chemical process development, advanced multi-step
organic synthesis, novel chemistries and technologies, the Company
operates two facilities near Milwaukee, Wisconsin including process
chemistry laboratories, kilo laboratories, a pilot plant, and
complete analytical laboratory. The Company has been FDA inspected
and approved for cGMP manufacturing.
At Cambridge Major, we provide a full range of chemistry servicesranging
from new route development (where no synthetic procedures exist),
to production using customer-supplied synthesis protocols. Based
on our expertise in a wide range of chemistries, we can accommodate
most small-molecule custom synthesis programs. Our equipment allows
us to handle projects ranging from -70C-130C, and pressures up
to 300 psi. We routinely handle alkyl lithium, azides, phosgene
and other difficult-to-handle reagents. Our chemistries are shown
below:
Palladium and Nickel Catalyzed Reactions
- Heck
- Sonogashira
- Suzuki and Related
Organometallic Chemistry
Heterocycles
- Pyridines
- Quinolones
- Thiophenes
- Oxazoles
- Piperazines
- Phenazines
- Indoles and Tryptophanes
- Ring Synthesis: Fischer, Batcho-Leimgruber, Muchowski,
Reissert, Japp-Klingemann, Moody, Madelung
- Ring Modification and Substitution
- Furanes
- Cu-Catalyzed Arylation
- Side-Chain Modification
- Aminoalkylation
Biphenyls and Fluorenes
- Synthesis: DMG-Snieckus and Suzuki
- Cyclizations: PPA, Friedel-Crafts and Eaton's
- Side-Chain Modification and Substitution
Amino Acids and Small Peptides
- Protection of Amino and Carboxylic Group
- Functional Modifications: Formation of Alcohols, Aldehydes,
Aminoketones, Carbonylimidazolides, Mixed Anhydrides, etc...
- Direct and Assisted by Auxiliary Reagents Peptide Bond Formation
Nucleosides and Sugars
- Synthesis and Modification of Nucleobase
- Protection, Modification and Deoxygenation of Ribose Ring
- Coupling and Deprotection
Reagents for Nucleotide Synthesis
- Phos Reagent
- Menpoc Chloride
Classical Organic Synthesis
- Acetoacylation, Acylation, Aldol Condensation, Alkoxylation,
Alkylation, Allylic Bromination, Amidation, Amination
- Benzoylation, Bromination
- Carbamoylation, Carboxylation, Chlorination, Chloromethylation,
Chlorosulfonation, Claisen Condensation, Cyclopropanations,
Cyanation, Cyclization
- Dealkylation, Decarboxylation, Dehalogenation, Dehydrogenation,
Deoxygenation,
Diazotization, Dieckmann Cyclization, Diels-Alder, Doebner-Knoevenagel
Condensation
- Esterification, Etherification
- Formylation, Friedel-Crafts, Fries Rearrangement
- Gomberg-Bachmann, Grignard
- Halide Exchange, Halogenation, Hofman Degradation, Hydroformylation,
Hydroxylation, Hydrogenation (low Pressure), Hydrolysis
- Kolbe-Schmitt, Ketalization
- Mannich, Micheal, Mitsunobu
- Nitration, Nitrosation
- Oxidation (Classical, TEMPO/NaOCl)
- Phosgenation
- Reduction, Reformatsky
- Sandmeyer, Saponification, Silylation, Sulfonation
- Thiophosgenation, Transesterification
- Ullmann
- Vilsmeier-Haack
- Williamson, Wittig
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Address
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Cambridge Major Laboratories Inc |
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N115 WI9392 Edison Drive, |
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Germantown,
WI 53022 |
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USA |
| Tel. |
+1 262 251 5044 |
| Fax |
+1 262 251 5577 |
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